Ducati has unveiled a special edition based on the Panigale V4 S that celebrates Marc Marquez' 2025 Moto GP victory. It also celebrates Ducati's fourth consecutive win and fifth win in its history. It is limited to just 293 units and features a few special touches.

Firstly, it gets the 2025 Ducati Lenovo team livery. It is lighter and more powerful than the Panigale V4 S from which it derives, and is enhanced with standard technical features. It gets an Akrapvic end-can that reduces weight by 2.5kg and also a dedicated engine tune that bumps power up to 218.5hp. 

It is equipped with Corner Sidepods, an aerodynamic solution introduced to MotoGP by Ducati in 2021 that generates ground effect at high lean angles. This ensures a higher level of tyre grip and allows for higher cornering speeds. It also gets 5-spoke forged carbon wheels that are lighter compared to the forged wheels on the S.

 It is also equipped with the Front Brake Pro+ front braking system, homologated for road use, which increases braking power and performance consistency. The special equipment is completed by the dry clutch, adjustable billet aluminium footpegs, and a GPS module. Those who wish to use it on the track will also have access to the billet aluminum racing fuel tank cap, brake caliper shrouds, an open carbon fibre clutch cover, and a license plate holder removal kit, all supplied as standard.

Like all Ducati collectibles, the Panigale V4 Márquez World Championship Replica is made unique by the machined-from-solid triple clamp featuring the model's name and unit number.

Unlike the V4 R that comes with a 999cc, homologated engine, the Ducati World Championship Replica continues to use the same 1,103cc engine that produces 218.5hp (up by 1.5hp) and 122.1Nm (up by 1.2Nm) of torque, mated to a six-speed gearbox.